Saturday, February 4, 2023

Fed State – Blood Glucose Regulation Part 1


#Diabetes #BloodGlucoseRegulation #Insulin

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This video is taken from a series of live webinars on Diabetes Mellitus by Dr. Najeeb.
Part 2 of this video lecture which will be uploaded soon discusses how Insulin will act on its target organs especially the liver.

In this lecture, Dr. Najeeb discusses the normal glucose level and its importance in the body. He then discusses about the absorptive state (fed state) and the metabolic pathways related to it. He also discusses the role of incretins and the phenomenon of the “incretin effect”. The organs involved in glucose homeostasis are then discussed along with the effect of glucose on beta cells and the role of GLUT-2 channels in the uptake of glucose in various cells. An overview of insulin synthesis and secretion is then given in addition to the role of C-peptide and amylin. In the end, he gives summarizes the importance of portal circulation in maintaining glucose levels in the normal range in the systemic circulation.

Time Stamps

● Normal glucose level and its importance
00:00:00 – 00:05:44

● Fed state – An overview
00:05:44 – 00:10:42

● Role of Incretins
00:10:42 – 00:21:07

● “Incretin Effect”
00:21:07 – 00:24:08

● Organs involved in glucose homeostasis
00:24:08 – 00:27:02

● Effect of glucose on beta cells and the role of GLUT-2
00:27:02 – 00:40:50

● Insulin synthesis and secretion
00:40:50 – 00:49:49

● Effect of glucose on hepatocytes
00:49:49 – 00:51:48

● Overview of portal circulation and structure of hepatic lobule
00:51:48 – 1:11:27

● Significance of C-peptide levels
1:11:27 – 1:13:27



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